A publication of the American Thyroid Association, Change In Thyroid Nodule Volume Calculator, Find an Endocrinology – Thyroid Specialist, Clinical Thyroidology for the Public (CTFP). Patients with classical papillary thyroid cancer had a higher 5-year disease-free survival rate (92.7%) as compared with those with focal tall-cell change (76.3%) and tall-cell variant (62.2%). See this image and copyright information in PMC. The authors of this study tried to determine if tall-cell variant of microcarcinoma is more aggressive than the classic type of papillary microcarcinoma. Soares P, Póvoa AA, Melo M, Vinagre J, Máximo V, Eloy C, Cameselle-Teijeiro JM, Sobrinho-Simões M. Endocr Pathol. Oncol Lett. 4 TALL CELL VARIANT (Hernandez-Prera et al Thyroid 2017. Long non-coding (lnc)RNA PAPAS overexpression inhibits tumor growth in papillary thyroid carcinoma by downregulating lncRNA HOTTIP. Epub 2020 Aug 17. 964 - 974 Almost all tall-cell featured papillary thyroid cancers are created equal. 2020 Jul;37(7):3112-3128. doi: 10.1007/s12325-020-01391-1. The objective of this study was to investigate the incidence, survival, and disease recurrence of patients with TCV and compare them with other PTC in a whole population. Clipboard, Search History, and several other advanced features are temporarily unavailable. Compared with classical PTC, TCV patients presented at an older age (54.3 years vs. 46.3 years, p < 0.0001) had a higher rate of ETE (53.6% vs. 30.2%, p < 0.0001) and poorer 5-year disease-specific survival (81.9% vs. 97.8%, p < 0.0001). Study of 39 cases reviewed by 14 expert pathologists. The aggressive behavior has been ascribed to the histologic subtype and/ or to the clinicopathologic features, an issue that remains controversial. Prognostic implications of papillary thyroid carcinoma with tall-cell features. THE FULL ARTICLE TITLE Papillary thyroid carcinoma (PTC) is the most common malignant endocrine tumor. Ho AS, Luu M, Barrios L, Balzer BL, Bose S, Fan X, Walgama E, Mallen-St Clair J, Alam U, Shafqat I, Lin DC, Chen Y, Van Eyk JE, Maghami EG, Braunstein GD, Sacks WL, Zumsteg ZS. Tall cell variant papillary thyroid carcinoma (TCV) was first described in 1976 by Hawk and Hazard as an aggressive histological variant of papillary thyroid cancer [1 1. Studies have elucidated a better understanding of the clinical implications and pathophysiology of this variant. Six cases had aspirates with tall cells. 4. While this was the standard in the past, we now know that in specific situations immediate surgery may not be necessary. In the matched-pair analysis comparing TCV patients to the matched PTC cohort, 5-year disease-specific survival was poorer in the TCV cohort (81.9% vs. 91.3%, p = 0.049). Prevention and treatment information (HHS). Axelsson TA, Hrafnkelsson J, Olafsdottir EJ, Jonasson JG. They had 2 separate pathologists re-review all of the slides and then compared outcomes of patients with <30% of cells that were tall-cell to patients with >30% of cells tall-cell. Methods: 1-3 However, there are a few patients … TCV is overrepresented in patients with RAI refractory disease. Several unique histologic subtypes of PTC have been associated with a more aggressive clinical course, including the tall cell variant (TCV), a subtype representing 5% to 10% of all PTCs. Conclusions: Among the 61 with PTC GD-positive, 59.0% presented with the pure papillary variant, 19.7% with the follicular variant, 6.6% with the sclerosing variant, and 18.0% with the tall cell variant (TCV) of PTC. The tumors had > 30% tall cells. A US doctor answered Learn more Aggressive form: The tall-cell variant of papillary thyroid cancer is a more aggressive tumor than common-type papillary cancer. Hum Pathol. “The results from this study fit extremely well with the recent TCGA (The Cancer Genome Atlas) study of papillary carcinoma, which demonstrated the classical, follicular and tall cell variants have distinct biological characteristics and genetic drivers,” said Dr. Giordano, who was co-chair of the TCGA study. B. Several variants are recognized, although classical papillary thyroid carcinoma is the most frequent; microscopic, follicular variant, diffuse sclerosing variant, tall cell variant, columnar cell variant, hobnail variant, among others. However, some papillary thyroid cancer variants have been shown to be more aggressive, showing higher rates of spread to both lymph nodes and outside of the neck as well as having increased rates of cancer recurrence and decreased survival. 2. There has been disagreement over what proportion of cells need be described as ‘tall-cell’ for patient outcomes to be worse. The diagnostic criteria remain inconsistent, … Prognostic Impact of Histologic Grade for Papillary Thyroid Carcinoma. The tall cell variant of papillary thyroid carcinoma is the most common aggressive variant of papillary thyroid carcinoma. Background: The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is an aggressive variant of PTC that is believed to have worse outcomes than classical PTC. Popular - most common malignant neoplasm of the thyroid. Unable to load your collection due to an error, Unable to load your delegates due to an error, Kaplan–Meier plot of DSS. Results: 8600 Rockville Pike Papillary thyroid carcinoma tall cell variant TCV is a biologically and clinically aggressive form of PTC that is still underdiagnosed. Five-year DSS for TCV (81.9%) vs. matched PTC (91.3%)…, National Library of Medicine Univariate and multivariate survival analyses. There are 4 variants of papillary thyroid cancer: classic, follicular, tall-cell and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). 2021 Apr;110:62-72. doi: 10.1016/j.humpath.2020.08.009. A comparison of the clinicopathological features and prognoses of the classical and the tall cell variant of papillary thyroid cancer: a meta-analysis. Those patients with a tall-cell proportion >10% should be targeted for more aggressive therapy and closer monitoring. Since the thyroid follicular epithelium is the non-squamous epithelium, how primary squamous cell carcinoma (SCC) of the thyroid occurs is still a controversial issue. Some authors have suggested that TCV can be effectively diagnosed on thyroid fine-needle aspiration (FNA); this diagnosis may help clinicians plan a more effective treatment regimen. Our objective was to utilize a large cancer registry to obtain sufficient power to differentiate between outcomes in cases of TCV and PTC. The tall-cell variant of papillary thyroid cancer makes up only about 1% of papillary thyroid cancers and is reported to be more aggressive than classic type of papillary thyroid cancer. After receiving a diagnosis of papillary thyroid cancer, intuitively, the thought has been that surgery is the next step. Minniejan, I too have the Tall Cell Variant of Papillary Thyroid Cancer (TCV). Would you like email updates of new search results? It has a high prevalence of B-RAF mutations making the latter an attractive target in … When these two variables are controlled for, it is unclear whether tall-cell histology alone portends a poor prognosis. After taking into account cancer size and other aggressive features, patients with <10% tall-cell features had significantly lower rates of persistent or recurrent disease compared to those with 10-30%, 20-30%, and >30% tall-cell features. A tall-cell proportion of <10% focal changes should be used as the cutoff for predicting outcomes, which can be used to help counsel patients on treatment and prognosis. Thyroid squamous cell carcinoma is very rare. Medical school memory device P's: 1. WHAT ARE THE IMPLICATIONS OF THIS STUDY? When the major prognostic factors for thyroid cancer are controlled for, including age and ETE, tall-cell histology alone remains a significant prognostic factor for disease-specific death. Accessibility W. A. Hawk and J. Tall cell variant of papillary thyroid carcinoma is the most common aggressive subtype. Tall cell variant (TCV) is an aggressive form of papillary thyroid carcinoma (PTC), usually associated with higher local recurrence and distant metastasis. RESULTS: Nineteen cases of the tall cell variant were identified in 229 cases of papillary thyroid carcinoma (8.5%) from 1957 to 1993. Please enable it to take advantage of the complete set of features! When these two variables are controlled for, it is unclear whether tall-cell histology alone portends a poor prognosis. Careers. Data set for reporting carcinoma of the thyroid: recommendations from the International Collaboration on Cancer Reporting. Papillary thyroid cancer: the most common type of thyroid cancer. They all appear to behave the same and have worse outcomes than classical papillary thyroid cancer. Cancer recurrence: this occurs when the cancer comes back after an initial treatment that was successful in destroying all detectable cancer at some point. Several studies have demonstrated a poorer prognosis for specific subtypes of papillary thyroid cancers, including tall cell, insular, and hobnail variants. Thyroid. Epub 2014 Nov 19. Epub 2019 May 21. Using the National Cancer Institute's Surveillance, Epidemiology, and End Results database, we identified 278 TCV patients and 2522 classical PTC patients with sufficient information for a detailed matched-pair analysis. PAPILLARY thyroid carcinoma (PTC) is the most common variety of thyroid cancer (70%-80% of cases) and the most common endocrine neoplasia. 1 Approximately 162 cases of … There were 131 patients with tall-cell papillary thyroid cancer (73% with <30% and 27% with >30% tall-cell cells) examined in this study and compared to 104 patients with classical papillary thyroid cancer. Ganly I, Ibrahimpasic T, Rivera M, Nixon I, Palmer F, Patel SG, Tuttle RM, Shah JP, Ghossein R. Thyroid. Tall Cell is a variant of the papillary thyroid cancer type, but the current thought is that it is more aggressive than classic papillary. 3. Tall cell variant of papillary thyroid carcinoma: a population-based study in Iceland. The incidence of thyroid cancer has increased significantly over the last three decades in large… Tall cell variant (TCV) of papillary thyroid carcinoma (PTC) accounts for approximately 6% of PTC and is considered an aggressive PTC subtype [1, 2].It has double the rate of extrathyroidal extension and nearly triple the rate of distant metastases compared to classic PTC; moreover, the recurrence rate and cause-specific death rate of TCV are 22% and … Papillary thyroid carcinoma tall cell variant. The tall cell (TC) variant of papillary thyroid carcinoma (PTC) has an unfavorable prognosis. Ann Surg Oncol. THE FULL ARTICLE TITLE: Ghossein R, Barletta JA, Bullock M, Johnson SJ, Kakudo K, Lam AK, Moonim MT, Poller DN, Tallini G, Tuttle RM, Xu B, Gill AJ. The tall cell variant of papillary carcinoma (TCV), first described by Hawk and Hazard (1), is defined by the presence of neoplastic cells having a … Tall cell variant (TCV) is an aggressive form of papillary thyroid carcinoma (PTC), usually associated with higher local recurrence and distant metastasis. The patients were females with a median age of 43 years, and all had aggressive neoplastic diseases. PMID: 31115855. How much more aggressive is still unknown. However, some papillary thyroid cancer variants have been shown to be more aggressive, showing higher rates of spread to both lymph nodes and outside of the neck as well as having increased rates of cancer recurrence and decreased survival. FOIA It accounts for about 1% of papillary cancers and is characterized by tumor cells with eosinophilic cytoplasm that are twice as tall as they are wide. Compare to WHO definition (2017): TALL CELL PTC SUMMARY OF THE STUDY Bongers PJ et al 2019 Papillary thyroid cancers with focal tall cell change are as aggressive as tall cell variants and should not be considered as low-risk disease Ann Surg Oncol. The Tall cell variant of papillary carcinoma of the thyroid (TCV) is characterized by the proliferation of oxyphilic, tall, columnar cells with a height‐to‐width ratio of at least 2:1. Because previous studies have been underpowered to adequately answer this question, we hypothesized that TCV may have poorer prognosis than PTC. BACKGROUND Correlation fair at best (kappa 0.39). FVPTC Follicular Variant of Papillary Thyroid Carcinoma, CVPTC Classical Variant of Papillary Thyroid Carcinoma, TCPTC Tall Cell Variant of Papillary Thyroid Carcinoma, ATA American Thyroid Association, AJCC American Joint Committee on Cancer. Well-differentiated papillary thyroid carcinoma (PTC) is the most common and the most prognostically favorable form of thyroid carcinoma. 2021 Mar;28(3):1731-1739. doi: 10.1245/s10434-020-09023-2. Aggressive variants of papillary thyroid cancer: incidence, characteristics and predictors of survival among 43,738 patients. Hashimoto’s thyroiditis (HT) is considered to be an independent risk factor for thyroid cancer, under the basis of HT, how … 2014 Apr;24(4):662-70. doi: 10.1089/thy.2013.0503. I was diagnosed with thyroid cancer in July, 2008. Thyroid 2008;18:1179–1181. Background: The tall-cell variant (TCV) of papillary thyroid carcinoma (PTC) is considered a more aggressive variant of PTC, with a poor prognosis. The prognosis for patients with PTC is almost the same as that of individuals who never had cancer, and only a few patients with PTC are affected by a biologically aggressive tumor [1,2].The most common of PTC aggressive subtypes is the tall cell variant (TCV). Epub 2020 Jan 21. Papillary thyroid carcinoma tall cell variant. Five-year DSS for TCV (81.9%) versus all PTC (97.8%)…, Kaplan–Meier plot of DSS. Epub 2011 Nov 8. At present, it is limited to case reports. The histopathologic criteria for the diagnosis of the tall cell variant of papillary thyroid carcinoma were a tumor composed of more than 50% tall cells, a tall cell height at least twice its width, eosinophilic tall cell cytoplasm, and nuclear features characteristic of papillary thyroid carcinoma such as nuclear irregularities, clearing overlapping grooves, and … One of these variants is tall-cell, which describes how the cells look under the microscope. 4, pp. Background: Epub 2020 Jun 1. Compared to the group of patients with classical papillary thyroid cancer, both tall-cell groups had higher rates of “aggressive” features, ie vascular invasion, gross extension of the cancer outside of the thyroid and spread to the lymph nodes in the neck. Thyroid Cancer (Papillary and Follicular): https://www.thyroid.org/thyroid-cancer/. The number of deaths in the TCV cohort was higher than in the matched PTC cohort (p = 0.043). Epub 2020 Sep 10. This site needs JavaScript to work properly. Patients with rare variants of papillary carcinoma thyroid need to be managed more aggressively than are those with classical papillary cancer of the same stage. Papillary thyroid cancer is the most common cause of thyroid cancer and most cases have excellent outcomes. View at: Google Scholar See in References ]. I had a total thyroidectomy in September 2008. All tall-cell variants of papillary thyroid cancer are created equal. A publication of the American Thyroid Association, Summaries for the Public from recent articles in Clinical Thyroidology, Table of Contents | PDF File for Saving and Printing, THYROID CANCER We herein report an unusual case of a 55-y-old woman with papillary carcinoma of the thyroid, who presented with multiple recurrences, with its subsequent evolution to tall cell variant and thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome. This is largely due to the tendency for TCV to present at an older age and with extrathyroidal extension (ETE). 2021 Mar;32(1):44-62. doi: 10.1007/s12022-021-09666-1. Home » Patients Portal » Clinical Thyroidology for the Public » October 2019 » Vol 12 Issue 10 p.9, CLINICAL THYROIDOLOGY FOR THE PUBLIC Classically, PTC has been classified as a well-differentiated thyroid cancer, together with follicular thyroid cancer, because of its good prognosis and low mortality rate. The majority of cases present with metastases to the lymph nodes or even distant metastases. CAS Article PubMed Google Scholar 48. 2015 Feb;25(2):216-20. doi: 10.1089/thy.2014.0075. The TCV cohort was then compared against all PTC cases and matched PTC cases. Liu Z, Zeng W, Chen T, Guo Y, Zhang C, Liu C, Huang T. Oncotarget. Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review. Ann Surg Oncol. Bethesda, MD 20894, Copyright Palpable lymph nodes. Most pathologists in this study defined TALL CELL PTC as cell 3 x tall as wide and that at least 30% of tumor shows tall cell cytology. Epub 2014 Jan 22. There's actually a lot of questions regarding the Tall Cell variant. This is largely due to the tendency for TCV to present at an older age and with extrathyroidal extension (ETE). Among 509 PTC GD-negative, 80.6% had pure papillary variant, 9.0% follicular variant, 3.7% sclerosing variant, and 6.1% TCV.

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